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KMID : 0381120220440111399
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Genes and Genomics
2022 Volume.44 No. 11 p.1399 ~ p.1404
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Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action
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Inokuchi Hachiro
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Abstract
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Background: The question of whether the coronavirus genome contain as-yetununderstood genetic component.
Purpose (Objective): Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents.
Methods: A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequences of these two viruses, it was found that base pairing in the cloverleaf model of SARS-CoV-2 was more robust than that of SARS-CoV.
Results: The results of homology search between a short sequence of the coronavirus tRNA-like base sequence and human genes suggest that the molecule produced by this novel tRNA-like sequence may be involved in the splicing of human messenger RNA.
Conclusions: Experimental molecular evidence of the tRNA-like base sequence discovered in this study is urgently needed.
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KEYWORD
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Coronavirus, Cloverleaf model of tRNA, Mutation, Base sequence, Intron
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